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KMID : 0363120070200010015
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Korean Journal of Pain
2007 Volume.20 No. 1 p.15 ~ p.20
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The Effect of Intravenous Lipo-Prostaglandin E1 Injectioin in a Rat Foraminal Stenosis Model
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Yoon Hye-Kyoung
Lee Pyung-Bok
Kim Yang-Hyun
Kim Yong-Chul
Lee Sang-Chul
Park Sang-Hyun
Lee Seung-Yoon
Han Jin-Soo
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Abstract
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Background: Lipo-prostaglandin E1 (Lipo-PGE1) has vasodilating and platelet aggregation inhibitory characteristics and it has been used as a treatment for patients with blood flow dysfunction disease. Based on the mechanisms of lumbar spinal stenosis, including veno congestion, neuro-ischemia and mechanical compression, we aimed to study whether intravenous Lipo-PGE1 injection has any therapeutic effect on hyperalgesia in a rat foraminal stenosis model.
Methods: In this study, twenty male Sprague-Dawley rats were divided into the control (n = 10) and Lipo-PGE1 (n = 10) groups. A small stainless steel rod was inserted into the L5-6 intervertebral foramen to induce intervertebral foramen stenosis and chronic DRG compression. In the Lipo-PGE1 group, 0.15μg/kg of Lipo-PGE1 were injected intravenously via a tail vein for 10 days starting from the 3rd day after operation. Behavioral testing for mechanical and thermal hyperalgesia was performed for 3 weeks after the injections.
Results: From the 10th day after Lipo-PGE1 injection, the rats in the experimental group showed significant recovery of their mechanical threshold, and this effect was maintained for 3 weeks. No significant differences of the thermal hyperalgesia were observed between the two groups.
Conclusions: These findings suggest that intravenously injected Lipo-PGE1 may be effective for alleviating neuropathic pain, which isthe main symptom of spinal stenosis, by improving the blood flow dysfunction.(Korean J Pain 2007; 20: 15-20)
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KEYWORD
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hyperalgesia, lipo-PGE1, spinal stenosis.
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